Depending on the natural, historical and economic conditions, the level of development of small business in different regions of each country is not the same. However, there is a common feature, which is the more intensive development of entrepreneurship skills in economic sectors. Current paper work discusses effect of small business into socio-economic development of Uzbekistan in the light of share in GDP and role of it in national economy. Main outcomes can be presented as econometric analyses which selected variables relationship and sectors of the small business current status in figures. Suggestions on increasing export potentials of the entrepreneurship presented in the next part of the research. Asa conclusion authors argue new ideas and targets on small business areas and oriented knowledge-based economy with professional skill and ability. The final part concludes improvement policy on small business in all major cities with integrity of enterprises, organizations, education and business.